Combining protein evolution and secondary structure
نویسندگان
چکیده
منابع مشابه
Combining protein evolution and secondary structure.
An evolutionary model that combines protein secondary structure and amino acid replacement is introduced. It allows likelihood analysis of aligned protein sequences and does not require the underlying secondary (or tertiary) structures of these sequences to be known. One component of the model describes the organization of secondary structure along a protein sequence and another specifies the e...
متن کاملCombining Statistical Models for Protein Secondary Structure Prediction
We investigate the problem of combining experts to predict the secondary structure of globular proteins. We first present two different statistical models for this task. We then analyse an efficient linear combination technique, this sheds light on unexplained phenomena frequently encountered in practice for ensemble methods.
متن کاملCombining co-evolution and secondary structure prediction to improve fragment library generation.
Motivation Recent advances in co-evolution techniques have made possible the accurate prediction of protein structures in the absence of a template. Here, we provide a general approach that further utilizes co- evolution constraints to generate better fragment libraries for fragment-based protein structure prediction. Results We have compared five different fragment library generation program...
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The past year has seen a consolidation of protein secondary structure prediction methods. The advantages of prediction from an aligned family of proteins have been highlighted by several accurate predictions made 'blind', before any X-ray or NMR structure was known for the family. New techniques that apply machine learning and discriminant analysis show promise as alternatives to neural networks.
متن کاملSecondary and tertiary protein structure I. Hierarchy of protein structure
Four levels in protein structural organization are commonly identified. Primary structure is a sequence of amino acids. Secondary structure is represented by regular local conformations of polypeptide chain, such as α-helix or β-strand. The combinations of two secondary structure elements are also sometimes referred to as secondary (or supersecondary) structure. The example is a β-hairpin forme...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 1996
ISSN: 0737-4038,1537-1719
DOI: 10.1093/oxfordjournals.molbev.a025627